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Lord Londonderry’s case was precisely of that order: he had been worried by a long session of Parliament, which adds the crowning irritation in the interruption of sleep. The nervous system, ploughed up by intense wear and tear, is denied the last resource of natural relief. In this crisis, already perilous, a new tempest was called in–of all the most terrific–the tempest of anxiety: and from what source? Anxiety from fear, is bad: from hope delayed, is bad: but worst of all is anxiety from responsibility, in cases where disease or weakness makes a man feel that he is unequal to the burden. The diplomatic interests of the country had been repeatedly confided to Lord Londonderry: he had justified that confidence: he had received affecting testimonies of the honor which belonged to such a situation. But a short time before his fatal seizure, in passing through Birmingham at a moment when all the gentlemen of the place were assembled, he had witnessed the whole assembly–no mob, but the collective good sense of the place–by one impulse standing bareheaded in his presence,–a tribute of disinterested homage which affected him powerfully, and which was well understood as offered to his foreign diplomacy. Under these circumstances could he bear to transfer or delegate the business of future negotiation? Could he suffer to lapse into other hands, as a derelict, the consummation of that task which thus far he had so prosperously conducted? Was it in human nature to do so? He felt the same hectic of human passion which Lord Nelson felt in the very gates of death, when some act of command was thoughtlessly suggested as belonging to his successor–‘Not whilst I live, Hardy; not whilst I live.’ Yet, in Lord Londonderry’s case, it was necessary, if he would not transfer the trust, that he should rally his enegies instantly: for a new Congress was even then assembling. There was no delay open to him by the nature of the case: the call was —now, now, just as you are, my lord, with those shattered nerves and that agitated brain, take charge of interests the most complex in Christendom: to say the truth, of interests which are those of Christendom.

This struggle, between a nervous systm too grievously shaken, and the instant demand for energy seven times intensified, was too much for any generous nature. A ceremonial embassy might have been fulfilled by shattered nerves; but not this embassy. Anxiety supervening upon nervous derangement was bad; anxiety through responsibility was worse; but through a responsibility created by grateful confidence, it was an appeal through the very pangs of martyrdom. No brain could stand such a siege. Lord Londonderry’s gave way; and he fell with the tears of the generous, even where they might happen to differ from him in politics.

Meantime, this case, belonging to a class generated by a London life, was in some quarters well understood even then; now, it is well known that, had different remedies been applied, or had the sufferer been able to stand up under his torture until the cycle of the symptoms had begun to come round, he might have been saved. The treatment is now well understood; but even then it was understood by some physicians; amongst others by that Dr. Willis who had attended George III. In several similar cases overpowering doses had been given of opium, or of brandy; and usually a day or two had carried off the oppression of the brain by a tremendous reaction.

In Birmingham and other towns, where the body of people called Quakers are accumulated, different forms of nervous derangement are developed; the secret principle of which turns not, as in these London cases, upon feelings too much called out by preternatural stimulation, but upon feelings too much repelled and driven in. Morbid suppression of deep sensibilities must lead to states of disease equally terrific and perhaps even less tractable; not so sudden and critical perhaps, but more settled and gloomy. We speak not of any physical sensibilities, but of those which are purely moral–sensibilities to poetic emotions, to ambition, to social gaiety. Accordingly it is amongst the young men and women of this body that the most afflicting cases under this type occur. Even for children, however, the systematic repression of all ebullient feeling, under the Quaker discipline, must be sometimes perilous; and would be more so, were it not for that marvellous flexibility with which nature adapts herself to all changes–whether imposed by climate or by situation–by inflictions of Providence or by human spirit of system.